15
Side Effects Contraindications
▶ Flushing
▶ Hyperglycemia
▶ Hyperuricemia (or gout)
▶ Upper GI distress
▶ Hepatotoxicity
Absolute:
▶ Unexplained hepatic dysfunction, active
peptic ulcer, arterial bleeding
Relative:
▶ DM
▶ Hyperuricemia
▶ Peptic ulcer disease
▶ Dyspepsia
▶ Gallstones
▶ Myopathy
▶ Unexplained non-CHD deaths
in WHO study using clofibrate
Absolute:
▶ Severe renal dysfunction or dialysis
▶ Active liver disease & unexplained
aminase elevation
▶ Gallbladder disease
▶ Nursing mothers
▶ Myalgia, rare
▶ ▶ LFT values
▶ Previous sensitivity
▶ Diarrhea
▶ Nausea
▶ Abdominal pain
or discomfort
▶ Eructation
Relative:
▶ Fish hypersensitivity
▶ Fishy taste
▶ ▶ bleeding time which does not
exceed normal limits
Relative:
▶ Fish hypersensitivity
▶ Eructation
▶ Dyspepsia
▶ Taste perversion
Relative:
▶ Fish hypersensitivity
▶ Fishy taste
▶ ▶ bleeding time which does not
exceed normal limits
Relative:
▶ Fish hypersensitivity
