Treatment
14
Table 15A. Single-Agents — Effects on Lipid Metabolism (cont'd)
Drug Class, Agents,
and Daily Doses Lipid/Lipoprotein Effects
Nicotinic acid
▶ Immediate-release crystalline
nicotinic acid (1.5-3 g)
Niacor
®
, Nicolar
®
▶ Extended-release nicotinic acid
(1-2 g) Niaspan
®
▶ Sustained-release nicotinic acid
(1-2 g) Slo-Niacin
®
LDL-C 5%-25%
HDL-C 15%-35%
TG 20%-45%
Fibric acids
▶ Gemfibrozil (600 mg bid)
Lopid
®
, generics
▶ Fenofibrate (various doses)
Antara
®
, Fenoglide
®
, Lipanthyl
®
,
Lipofen
®
, Lofibra
®
, Tricor
®
,
Triglide
®
, generics
▶ Fenofibric acid
Trilipix
®
(35-135 mg ),
Fibricor
®
(35-105 mg )
▶ Clofibrate (1,000 mg bid) generics
LDL-C 5%-20%
(may be increased in patients with high TG)
HDL-C 10%-20%
TG 20%-50%
Ezetimibe
▶ Zetia
®
LDL-C 15%-20%
HDL-C 1%-2%
TG 10%
Prescription Omega-3 Fatty Acids
▶ EPA and DHA omega-3-carboxylic
acids
Epanova
®
(2-4 g)
LDL-C 21%-26%
HDL-C neutral
TG 25%
▶ EPA and DHA omega-3-acid
ethyl esters
Lovaza
®
(4 g)
LDL-C neutral or increase
HDL-C neutral to 10%
TG 20%-45%
▶ EPA and DHA omega-3-acid ethyl
esters A
Omtryg™ (4.8 g)
LDL-C 20%
HDL-C 5%-7%
TG 25%-31%
▶ EPA ethyl esters (icosapent ethyl)
Vascepa
™
(4 g)
LDL-C not increased
HDL-C neutral
TG 20%-45%
