Treatment
Table 15B. Combination Drugs — Effects on Lipid Metabolism
Agents and Daily Doses
Lipid/Lipoprotein Effects
(vary with dosage used)
Extended-release niacin/lovastatin
▶ Advicor
®
500/20 to 2000/80 mg/day
LDL-C 34%-47%
HDL-C 24%-33%
TG 35%-48%
Apo B ≤40%
Extended-release niacin/simvastatin
▶ Simcor
®
500/20 to 2000/40 mg/day
LDL-C 34%-56%
HDL-C 15%-29%
TG 22%-38%
Apo B ≤50%
Ezetimibe/simvastatin
▶ Vytorin
®
10/10 to 10/80 mg/day
LDL-C 45%-60%
HDL-C 6%-10%
TG 23%-31%
Apo B ≤50%
Ezetimibe/atorvastatin
▶ Liptruzet
™
10/10 to 10/80 mg/day
LDL-C 53%-61%
HDL-C 7%-9%
TG 31%-40%
Apo B 43%-50%
16
Table 16. Agents for Homozygous Familial
Hypercholesterolemia
Agent Dose
Lipid/Lipoprotein
Effects
Mipomersen (Kynamro
®
)
200 mg once weekly subcut
LDL-C 21%
TG 18%
HDL-C 11%
Apo B 24%
Lomitapide ( Juxtapid
®
)
5 mg PO once daily ×
≥2 wks, then increase to
10, 20, 40 and 60 mg at
≥4 wk intervals as tolerated
LDL-C 40%
TG 45%
HDL-C 7%
Apo B 39%
