Table 1. Antibiotic Treatment of Complicated SSTIs Antimicrobial
Route
Penicillins (CWAA) Penicillin G
Piperacillin (Pipracil ® ) ) )
IV IV
β-Lactam/β-lactamase inhibitors (CWAA) Ampicillin/sulbactam (Unasyn® Ticarcillin/clavulanate (Timentin® Piperacillin/tazobactam (Zosyn®
)
Carbapenems (CWAA) Imipenem/cilastatin (Primaxin® Ertapenem (Invanz® Meropenem (Merrem®
) )
Cephalosporins (CWAA) Cephalexin (Keflex®
)
Cefazolin (Ancef ® Cefoxitin (Mefoxin® Cefuroxime (Zinacef ® Ceſtriaxone (Rocephin®
) )
Ceſtazidime (Ceptaz® Cefotaxime (Claforan®
)
, Fortaz® )
Fluoroquinolones (DNAIA) Ciprofloxacin (Cipro® Levofloxacin (Levaquin® Moxifloxacin (Avelox®
) )
Macrolides (PSIA) Erythromycin
Erythromycin ethylsuccinate Azithromycin (Zithromax® Clarithromycin (Biaxin® ) ) )
, Kefzol ® )
) )
IV IV IV
IV IV IV
Dose
12-24 MU/d (+ PSIA if severe) 3–4 gm q4–6h
1.5–3 g q6h
3.1 gm q4–6h; 50 mg/kg q4–6h 3.375 gm q6h; 100/12.5 mg/kg q8h
0.5–1.0 gm q6–8h; 15-25 mg/kg q6–12h 1 gm qd; 15 mg/kg bid 500 mg q8h
PO Adult: 1–4 gm/d; Children: 25–50 mg/kg
IV IV IV
0.5–1.5 gm q6–8h 1–2 gm q6–8h 750 mg q8h
IV, IM Adult: 1–2 gm qd; Children: 50–75 mg/kg qd
IV, IM 500 mg –1 gm q8h ≤ 2 gm q4h
IV
PO, IV 500–750 mg q12h PO, IV 250–750 mg q24h PO, IV 400 mg q24h
PO 250 mg q6h OR 500 mg q12h
PO Adult: 400 mg q6h; Children: 30–50 mg/kg/d
PO 500 mg as a single dose on Day 1, followed by 250 mg qd on Days 2 through 5.
PO 250 mg q12h
