Table 1. Antibiotic Treatment of Complicated SSTIs (continued) Antimicrobial
Route
Tetracyclines (PSIA) Tetracycline Doxycycline
Minocycline (Minocin®
Tigecycline (Tygacil® Miscellaneous
) (PSIA) ) )
Quinupristin-dalfopristin (Synercid®
Clindamycin (Cleocin® (PSIA)
Vancomycin (CWAA) Linezolid (Zyvox®
Daptomycin (Cubicin® , others) ) (PSIA) Dose PO 250 mg qid OR 500 mg bid PO, IV Adults: Initial 200 mg, then 100 mg/d
PO, IV Adults: Initial 200 mg, then 100 mg q12h; Children >8 yr: Initial 4 mg/kg, then 2 mg/kg q12h
IV IV
IV, IM PO
IV
100 mg, then 50 mg q12h 7.5 mg/kg q12h
600–1200 mg/day 500 mg q6h OR 1 gm q12h PO, IV 600 mg q12h; 10 mg/kg q8h ) (CWAA) IV 4 mg/kg q24h
Table 2. Rank Order of Bacterial Pathogens Producing Skin and Soft Tissue Infections in North America, 1998–2004 Rank 1 2 3 4 5 6 7 8 9
Pathogen
Staphylococcus aureus Pseudomonas aeruginosa Enterococcus spp. Escherichia coli Enterobacter spp. Klebsiella spp.
β-hemolytic Streptococcus Proteus mirabilis
10
Coagulase-negative Staphylococcus Serratia spp.
No. of Isolates (% of Total) 2,602 (44.6) 648 (11.1) 542 (9.3) 422 (7.2) 282 (4.8) 248 (4.2) 237 (4.1) 166 (2.8) 161 (2.8) 125 (2.1)
