Table 4. Dosing of Antiretroviral Drugs for HIV-Infected
Adults With CKD or ESRD (continued)
Antiretroviral
Drug and Dosing
Category Dosage Comments
Nucleoside reverse transcriptase inhibitors (NRTIs) (continued)
Emtricitabine
CrCl ≥50 mL/min 200 mg PO daily
CrCl 30-49 mL/min 200 mg PO q48h
CrCl 15-29 mL/min 200 mg PO q72h
CrCl <15 mL/min 200 mg PO q96h
Receiving HD 200 mg PO q96h
a
Receiving PD Unknown, use with caution (dose
reduction needed)
Tenofovir disoproxil fumarate
CrCl ≥50 mL/min 300 mg PO daily
CrCl 30-49 mL/min 300 mg PO q48h is guideline
recommends
avoiding tenofovir
in patients with
CrCl <50 mL/
min who are not
on HD
CrCl 10-29 mL/min 300 mg PO q72-96h
Receiving HD 300 mg PO every 7 d
a
(an additional dose
may be needed if >12 h HD per week)
Receiving PD Unknown, use with caution (dose
reduction needed)
Emtricitabine/tenofovir disoproxil fumarate
CrCl ≥50 mL/min 200 mg/300 mg PO daily
CrCl 30-49 mL/min One tablet PO q48h
CrCl <30 mL/min Should not use combination tablet
Treatment
10
