Table 4. Dosing of Antiretroviral Drugs for HIV-Infected
Adults With CKD or ESRD (continued)
Antiretroviral Drug and
Dosing Category Dosage Comments
Nucleoside reverse transcriptase inhibitors (NRTIs) (continued)
Stavudine
Body weight ≥60 kg
CrCl >50 mL/min 40 mg PO bid (WHO recommends
30 mg PO bid)
CrCl 26-50 mL/min 20 mg PO bid
CrCl ≤25 mL/min 20 mg PO daily
Receiving HD 20 mg PO daily
a
Receiving PD Unknown, use with caution (dose
reduction needed)
Body weight <60 kg
CrCl >50 mL/min 30 mg PO bid
CrCl 26-50 mL/min 15 mg PO bid
CrCl ≤25 mL/min 15 mg PO daily
Receiving HD 15 mg PO daily
a
Receiving PD Unknown, use with caution (dose
reduction needed)
Didanosine delayed-release capsules
Body weight ≥60 kg
CrCl ≥60 mL/min 400 mg PO daily
CrCl 30-59 mL/min 200 mg PO daily
CrCl 10-29 mL/min 125 mg PO daily
CrCl <10 mL/min 125 mg PO daily
Receiving HD 125 mg PO daily
a
Receiving PD 125 mg PO daily
Body weight <60 kg
CrCl ≥60 mL/min 250 mg PO daily
CrCl 30-59 mL/min 125 mg PO daily
CrCl 10-29 mL/min 125 mg PO daily
CrCl <10 mL/min, HD,
or PD
Do not use didanosine delayed-
release capsules; use 75 mg (pediatric
powder for suspension) daily
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