Table 4. Dosing of Antiretroviral Drugs for HIV-Infected
Adults With CKD or ESRD (continued)
Antiretroviral
Drug and Dosing
Category Dosage Comments
Non-nucleoside reverse transcriptase inhibitors (NNRTIs)
b
Nevirapine 200 mg PO bid (aer 2 wks of 200 mg
PO daily)
Efavirenz 600 mg PO qhs
Delavirdine 400 mg PO tid
Etravirine 200 mg PO bid
Rilpivirine 25 mg PO daily
Protease inhibitors (PIs)
b
Indinavir 800 mg PO bid (in combination with
ritonavir 100 mg bid)
Saquinavir 1000 mg PO bid (in combination with
ritonavir 100 mg bid)
Nelfinavir 1250 mg PO bid or 750 mg tid
Fosamprenavir 1400 mg PO daily (in combination with
ritonavir 100-200 mg daily) OR 700 mg
PO bid (in combination with ritonavir
100 mg bid)
Ritonavir (used in
combination with
a second PI as a
pharmacokinetic
enhancer)
100-400 mg daily
Lopinavir/ritonavir 400 mg/100 mg PO bid OR 800 mg/200
mg PO daily. LPV trough lower in HD
(use with caution in PI-experienced
patients)
Atazanavir 400 mg PO daily OR 300 mg PO daily
(in combination with ritonavir 100 mg
PO daily). Avoid unboosted ATV in
HD. Avoid boosted ATV in treatment-
experienced patients on HD.
Darunavir 800 mg PO daily (in combination with
ritonavir 100 mg PO daily) OR 600 mg
PO bid (in combination with ritonavir
100 mg bid)
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