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Table 22. Antiretroviral Therapy and Statin Drug Interactions
(cont'd)
Statin Antiretroviral Drug Recommendations
Integrase Strand Transfer Inhibitors
Atorvastatin Bictegravir
Dolutegravir
Raltegravir
No dose adjustment needed.
Elvitegravir/cobicistat Titrate statin dose carefully and administer the
lowest effective dose while monitoring adverse
events. Do not exceed atorvastatin 20 mg daily.
Lovastatin Bictegravir
Dolutegravir
Raltegravir
No dose adjustment needed.
Elvitegravir/cobicistat Contraindicated.
Pitavastatin
Pravastatin
Bictegravir
Dolutegravir
Raltegravir
No dose adjustment needed.
Elvitegravir/cobicistat No data available for dose recommendation.
Rosuvastatin Bictegravir
Dolutegravir
Raltegravir
No dose adjustment needed.
Elvitegravir/cobicistat Titrate statin dose carefully and use the lowest
effective dose while monitoring for adverse events.
Simvastatin Bictegravir
Dolutegravir
Raltegravir
No dose adjustment needed.
Elvitegravir/cobicistat Contraindicated.
NNRTI indicates non-nucleoside reverse transcriptase inhibitor; and NRTI, nucleoside
reverse transcriptase inhibitor.
Adapted from and modified with permissions from Sarkar et al. Copyright © 2000–2025
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