76
Management
Table 22. Antiretroviral Therapy and Statin Drug Interactions
(cont'd)
Statin Antiretroviral Drug Recommendations
NNRTIs
Atorvastatin Doravirine
Rilpivirine
No dose adjustment needed.
Efavirenz
Etravirine
Adjust atorvastatin dose according to lipid
response, but do not exceed the maximum
recommended dose.
Nevirapine Adjust atorvastatin dose according to lipid
response, but do not exceed the maximum
recommended dose.
Fluvastatin Doravirine
Rilpivirine
Nevirapine
No dose adjustment needed.
Efavirenz
Etravirine
Dose adjustments for fluvastatin may be
necessary. Monitor for fluvastatin toxicity.
Lovastatin
Simvastatin
Doravirine
Rilpivirine
No dose adjustment needed.
Efavirenz Adjust simvastatin dose according to lipid
response, but do not exceed the maximum
recommended dose.
Etravirine
Nevirapine
Adjust lovastatin or simvastatin dose according
to lipid response, but do not exceed the
maximum recommended dose.
Pitavastatin All NNRTIs No dose adjustment needed.
Pravastatin Doravirine
Rilpivirine
Nevirapine
No dose adjustment needed.
Efavirenz
Etravirine
Adjust statin dose according to lipid
responses, but do not exceed the maximum
recommended dose.
Rosuvastatin All NNRTIs No dose adjustment needed.
NRTIs
All statins All NRTIs No dose adjustment needed.
