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Dyslipidemia 2026

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81 Without ASCVD or Diabetes (Fasting TG ≥150 mg/dL or nonfasting TG ≥175 mg/dL to 499 mg/dL)* Severe Hypertriglyceridemia (TG ≥500 mg/dL, and especially TG ≥1000 mg/dL)* Optional Interventions to Consider • Referral to a registered dietitian nutritionist • Addition of TG risk-based medication • Screening for familial chylomicronemia syndrome • Referral to lipid specialist Persistent fasting hypertriglyceridemia Factors to Consider • Evaluate and manage secondary cause of hypertriglyceridemia • Optimize diet and lifestyle interventions for hypertriglyceridemia • Implement guideline-directed statin therapy in appropriate patients and optimize statin adherence • Optimize glycemic control • Monitor response to therapy and adherence • Conduct clinician-patient discussion of potential benefits, potential harms, and preference

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