80
Management
Figure 14. Managing Adults With Hypertriglyceridemia
ASCVD and
Hypertriglyceridemia
(Fasting TG >150 to 499 mg/dL
or nonfasting TG >175 to 499
mg/dL and TG <500 mg/dL)*
Diabetes, Aged >40 y,
Without ASCVD and
Hypertriglyceridemia
(Fasting TG ≥150 mg/dL to
499 mg/dL or nonfasting TG
≥175 mg/dL to 499 mg/dL)*
Factors to Consider
• Evaluate and manage secondary cause of hypertriglyceridemia
• Optimize diet and lifestyle interventions for hypertriglyceridemia
• Implement guideline-directed statin therapy in appropriate patients
and optimize statin adherence
• Optimize glycemic control
• Monitor response to therapy and adherence
• Conduct clinician-patient discussion of potential benefits, potential
harms, and preference
Optional Interventions to Consider
• Referral to a registered dietitian nutritionist
• Addition of TG risk-based medication
• Screening for familial chylomicronemia syndrome
• Referral to lipid specialist
Persistent fasting hypertriglyceridemia
* Conversion of TG from mg/dL to mmol/L: 150 mg/dL=1.7 mmol/L, 175 mg/dL=2 mmol/L,
500 mg/dL to 5.7 mmol/L, 1000 mg/dL=11.3 mmol/L.
ASCVD indicates atherosclerotic cardiovascular disease; and TG, triglycerides.
Adapted with permission from Virani et al. Copyright © 2021 American College of Cardiology
Foundation.
