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Adults with Differentiated THyroid Cancer - 2025 Update

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12 Treatment Recommendation 23 A. Visual identification of the RLNs should be performed during thyroidectomy and/or para-tracheal node dissection, to preserve nerve integrity and function. (GPS) B. Intraoperative neurophysiological monitoring of the recurrent laryngeal nerve(s) may be performed during thyroidectomy for malignancy in an effort to reduce the risk of RLN injury, particularly during total or re-operative thyroidectomy. (C-L/M) C. Intraoperative identification and neurophysiological monitoring of the external branch of the superior laryngeal nerve (EBSN) may be performed during thyroidectomy for malignancy in an effort to improve accurate nerve identification and improve voice outcomes. (C-M/H) D. Intraoperative vagal nerve or proximal RLN stimulation (with monitoring or laryngeal palpation) should be performed after initial lobectomy to assess RLN integrity and function prior to removing the contralateral lobe in an effort to avoid possible bilateral nerve injury. (GPS) Recommendation 24 A. The parathyroid glands and their blood supply should be preserved during thyroid surgery to reduce the risk of hypoparathyroidism. Parathyroid glands, if devascularized or removed, should be auto- transplanted into nearby muscle after frozen section (of a portion) confirms benign parathyroid tissue. (GPS) B. After total thyroidectomy and/or central lymph node dissection, or after unilateral operations that follow prior contralateral thyroid resections, parathyroid hormone-directed calcium and vitamin D supplementation (regular or selective) should be provided to reduce rates of hypocalcemia and shorten hospital stays compared to observation with serial calcium measurement alone. (S-M) Recommendation 25 ➤ Under most circumstances, drainage of the thyroidectomy bed is not recommended; it is associated with increased length of stay, may increase infections, and does not reduce the incidence of hematoma. (C-H)

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