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Adults with Differentiated THyroid Cancer - 2025 Update

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13 Recommendation 26 A. Patients should have their voice assessed in the post-operative period. Formal laryngeal exam should be performed if the voice is abnormal. (GPS) B. Important intraoperative findings and details of post-operative care should be communicated by the surgeon to the patient and other physicians who are important in the patient's post-operative care. (GPS) C. If there is known recurrent laryngeal nerve injury from surgery, timely referral to a speech language pathologist and physician specializing in voice is recommended. (GPS) Recommendation 27 A. In addition to the essential histopathologic features of the tumor required for the latest AJCC thyroid cancer staging (including status of resection margins), pathology reports should include additional information helpful for risk assessment, including the presence of vascular invasion and the number of invaded vessels, number of lymph nodes examined and involved with tumor, size of the largest metastatic focus to the lymph nodes, and presence or absence of extranodal extension of the metastatic tumor. (GPS) B. Histopathologic subtypes of DTC associated with unfavorable (e.g., tall cell, columnar cell, and hobnail subtypes of PTC; widely invasive FTC and OTC; high grade follicular cell derived non-advanced thyroid cancer [ATC]) or favorable (e.g., invasive encapsulated follicular variant of papillary thyroid carcinoma [IEFVPTC] with minimal invasion, minimally-invasive FTC) outcomes should be identified during histopathologic examination and reported. (GPS) C. Histopathologic subtypes associated with familial syndromes (cribriform-morular carcinoma can be associated with familial adenomatous polyposis, PTEN-hamartoma tumor syndrome associated FTC or PTC) should be identified during histopathologic examination and reported. (GPS)

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