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Adults with Differentiated THyroid Cancer - 2025 Update

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11 Recommendation 20 A. Therapeutic central-compartment (Level VI and upper Level VII) neck dissection for patients with clinically involved central nodes (cN1a) should accompany thyroidectomy to clear disease from the central neck. (S-M) B. Therapeutic central lymph node dissection (CLND) with dissection of the ipsilateral central compartment lymph nodes is recommended to accompany lateral-compartment neck dissection and thyroidectomy for patients with clinically involved lateral neck lymph nodes (cN1b). (C-L) C. Therapeutic lateral neck compartmental lymph node dissection, typically including Levels IIa, III, IV and Vb, should be performed as part of initial surgical therapy for patients with biopsy-proven or clinically obvious metastatic lateral compartment cervical lymphadenopathy. (S-M) Recommendation 21 ➤ Prior to surgery, the surgeon should review surgical risks with the patient, including potential for nerve and parathyroid injury, through the informed consent process and communicate with associated physicians, including anesthesia colleagues, important findings elicited during the preoperative evaluation. (GPS) Recommendation 22 A. All patients undergoing thyroid surgery should undergo voice assessment as part of their pre-operative physical examination. This should include the patient's description of vocal changes and the physician's assessment of voice. (S-M) B. Preoperative laryngeal exam should be performed in all patients with: a. Preoperative dysphonia. (S-M) b. History of cervical or upper chest surgery, which places the recurrent laryngeal nerve or vagus nerve at risk. (S-M) c. Known thyroid cancer with posterior extrathyroidal extension or extensive central compartment or jugular chain nodal metastases. (S-L)

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