In adults with overweight (BMI ≥27 kg/m
2
and weight-related
complications) or obesity (BMI ≥30 kg/m
2
), with inadequate
response to lifestyle interventions, add pharmacological therapy
a
(Strong recommendation, moderate certainty)
Anti-obesity medications
Given the chronic
nature of obesity
management, many
practitioners use
these medications
longer than 12 weeks
in an off-label fashion
Orlistat
Gelesis100
superabsorbent
hydrogel
Suggest
against using
No
recommendation
2.8% 2.0%
Diethylpropion Phentermine
Suggest using
5.4% 3.6%
