Table 1. Anti-obesity Medications
Agent Brand name Dose Contraindications
a
Diethylpropion Generic 25 mg tid PO one
hour before meals;
75 mg sustained-
release tab PO mid-
morning
Pulmonary hypertension,
advanced arteriosclerosis,
hyperthyroidism, known
hypersensitivity or idiosyncrasy
to the sympathomimetic
amines, glaucoma, severe
hypertension
Gelesis100 oral
superabsorbent
hydrogel
Plenity ree with water
before meals
Risk factors for bowel
obstruction
Liraglutide Saxenda 3 mg daily
subcutaneous
(subcut)
Personal or family history of
medullary thyroid carcinoma
(MTC) or in patients with
Multiple Endocrine Neoplasia
syndrome type 2 (MEN 2)
Naltrexone-
bupropion ER
Contrave 32 mg/180 mg bid Seizure disorder, opiate therapy,
monoamine oxidase inhibitors
(MAOIs), severe renal or
hepatic disease. Caution advised
in patients at high risk of
seizures
Phentermine Generic
Adipex,
Suprenza,
Lomaira
4–8 mg tid;
15–37.5 mg qAM
Cardiovascular disease, MAOIs,
hyperthyroidism, history of
drug abuse, uncontrolled
hyperension
Phentermine-
topiramate ER
Generic
Qsymia
7.5 mg/46 mg qAM
or 15 mg/92 mg
qAM
Phentermine:
Cardiovascular disease, MAOIs,
hyperthyroidism, history of
drug abuse, uncontrolled
hyperension
Topiramate:
Associated with an increassed
risk of teratogenicity,
specifically oral cles
Semaglutide Wegovy 2.4 mg subcut weekly Personal or family history
of MTC or in patients with
MEN 2
a
All AOMs should be avoided during pregnancy and nursing.
