Treatment
Figure 1. Pharmacological Interventions for Adults With Obesity
Clinical Decision Support Tool
If failure to achieve adequate weight loss
(e.g., 5% reduction in total body weight)
and/or unable to control weight-related
complications, consider change in therapy
based on patient factors (switching drugs,
endoscopic bariatric procedures,
and/or bariatric surgery)
a
a
Selection of the medication or intervention should be based on the clinical
profile and needs of the patient including but not limited to complications,
patients' preferences, costs, and access to the therapy.
Semaglutide Liraglutide
Phentermine-
topiramate
ER
Naltrexone-
bupropion
ER
AGA
Recommendation
Suggest using
Mean difference
% total body weight
loss achieved
(placebo subtracted)
10.8% 4.8% 8.5% 3.0%
