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41 Other Comorbidities COR LOE Recommendations Hypertension Aer Renal Transplantation IIa SBP: B-NR Aer kidney transplantation, it is reasonable to treat patients with hypertension to a BP goal of less than 130/80 mm Hg. DBP: C-EO IIa B-R Aer kidney transplantation, it is reasonable to treat patients with hypertension with a calcium antagonist on the basis of improved GFR and kidney survival. Peripheral Artery Disease I B-NR Adults with hypertension and PAD should be treated similarly to patients with hypertension without PAD. Diabetes Mellitus I SBP: B-R SR In adults with DM and hypertension, antihypertensive drug treatment should be initiated at a BP of 130/80 mm Hg or higher with a treatment goal of less than 130/80 mm Hg. DBP: C-EO I A SR In adults with DM and hypertension, all first-line classes of antihypertensive agents (i.e., diuretics, ACE inhibitors, ARBs, and CCBs) are useful and effective. IIb B-NR In adults with DM and hypertension, ACE inhibitors or ARBs may be considered in the presence of albuminuria. Atrial Fibrillation IIa B-R Treatment of hypertension with an ARB can be useful for prevention of recurrence of atrial fibrillation (AF). Valvular Heart Disease I B-NR In adults with asymptomatic aortic stenosis, hypertension should be treated with pharmacotherapy, starting at a low dose and gradually titrating upward as needed. IIa C-LD In patients with chronic aortic insufficiency, treatment of systolic hypertension with agents that do not slow the heart rate (i.e., avoid beta blockers) is reasonable. Aortic Disease I C-EO Beta blockers are recommended as the preferred antihypertensive agents in patients with hypertension and thoracic aortic disease.

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