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High Blood Pressure

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25 Physical Examination Findings Screening Tests Confirmatory Tests Signs of virilization (11-beta-OH) or incomplete masculinization (17-alpha-OH) Hypertension and hypokalemia with low or normal aldosterone and renin 11-beta-OH: elevated DOC, 11-deoxycortisol, and androgens; 17-alpha- OH; decreased androgens and estrogen but elevated DOC and corticosterone Arrhythmias (with hypokalemia) Low aldosterone and renin Urinary cortisol metabolites; genetic testing Acral features; large hands and feet; frontal bossing Serum growth hormone ≥1 ng/mL during oral glucose load Elevated age- and sex- matched IGF-1 level; MRI scan of the pituitary

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