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ASCOBIOHen06222a
Disclaimer
is pocket guide is derived om recommendations in the American Society of Clinical Oncology
Guideline. is resource is a practice tool based on ASCO® practice guidelines and is not intended
to substitute for the independent professional judgment of the treating physician. Practice guidelines do
not account for individual variation among patients. is pocket guide does not purport to suggest any
particular course of medical treatment. Use of the practice guidelines and this resource are voluntary.
e practice guidelines and additional information are available at www.asco.org/breast-cancer-
guidelines. Copyright © 2022 by American Society of Clinical Oncology. All rights reserved.
Abbreviations
BRCA1, BReast CAncer gene 1; BRCA2, BReast CAncer gene 2; CA, cancer antigen;
CEA, carcinoembryonic antigen; ctDNA, circulating tumor DNA; CTC, circulating
tumor cell; dMMR, deficient mismatch repair; ER, estrogen receptor; ESR1, estrogen
receptor 1 gene; FDA, United States Food and Drug Administration; HER2, human
epidermal growth factor receptor 2; HRD, homologous recombination deficiency;
MBC, metastatic breast cancer; MSI, microsatellite instability; MSI-H, microsatellite
instability-high; NTRK, neurotrophic tyrosine receptor kinase; PARP, poly (ADP-
ribose) polymerase; PD-L1, programmed cell death ligand-1; PR, progesterone receptor;
SERD, selective estrogen receptor degrader; TMB, tumor mutational burden; TROP2,
trophoblast cell-surface antigen 2
Source
Henry NL, Somerfield MR, Dayao Z, et al. Biomarkers for Systemic erapy in Metastatic
Breast Cancer: ASCO Guideline Update. J Clin Oncol. 2022 June 27. doi: 10.1200/
JCO.22.01063.
ASCO believes that cancer clinical trials are vital to inform medical decisions and
improve cancer care and that all patients should have the opportunity to participate.
Additional information, which may include data supplements, slide sets, and other clinical
tools and resources, is available at www.asco.org/breast-cancer-guidelines.
