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Table 1. At-A-Glance Guide to ASCO Biomarker Testing in
Metastatic Breast Cancer Recommendations
Biomarker Tests Recommended by the ASCO Expert Panel
Test Recommendation grade
• PIK3CA
• Germline BRCA1 and BRCA2
• PD-L1
Strong recommendation; EB-B-H
Strong recommendation; EB-B-H
Strong recommendation; EB-B-I
• dMMR/MSI-H
• TMB
• NTRK fusions
Moderate recommendation; IC-L
Moderate recommendation; IC-L
Moderate recommendation; IC-L
Biomarker Tests Not Recommended by the ASCO Expert Panel
Test Recommendation grade
• ESR1
• PALB2
Moderate recommendation; EB-Ins
Moderate recommendation; EB-L
• HRD
• TROP2 expression
• ctDNA
• CTCs
Moderate recommendation; IC-L
Moderate recommendation; IC-L
Moderate recommendation; IC-L
Moderate recommendation; IC-L
