14
Anti-obesity Pharmacotherapy
Anti-obesity Medication Summary
Agent/Dose Description
Main Side Effects/
Adverse Reactions
Naltrexone/
bupropion
(Contrave ER)
Dose:
Tablets to be taken
twice daily not at
meals
8 mg/90 mg
increased weekly
×
4
• Combination of
naltrexone (opioid
antagonist used
for addictions) and
bupropion (used
for depression and
smoking cessation).
• Average weight loss
5-6% of body weight
Nausea, constipation,
headache, vomiting,
dizziness, insomnia, dry
mouth, diarrhea, and
acute closure glaucoma.
Bupropion can increase
the risk of suicide
ideation thinking in
children, adolescents,
and young adults
(cont'd)
