13
Some Drug Interactions Contraindications
• Cyclosporine should be taken at
least 3 hours before or after orlistat
as orlistat reduces cyclosporine
absorption and plasma levels.
• Orlistat reduces beta-carotene
supplement absorption by
30% and vitamin E acetate
supplement by 60%.
• Orlistat reduces vitamin K
absorption and plasma levels.
Therefore, patients on warfarin
should be monitored closely
for changes in coagulation
parameters.
• Orlistat may reduce levothyroxine
absorption. Therefore
levothyroxine and orlistat should
be administered at least 4 hours
apart.
• Chronic malabsorption
syndrome
• Cholestasis
