10
Treatment
Table 2b. Doses of Drugs for Treatment of Adults and
Children with MDR-TB
STEP Drug
Route of
Admin-
istration Adults
1 Levofloxacin PO / IV
750–1000 mg daily
b
Moxifloxacin PO / IV
400–(600–800 mg ) daily
c
2 Bedaquiline PO 400 mg daily × 14 days then
200 mg 3×/week
Linezolid PO / IV 600 mg daily
3 Clofazimine PO 100 mg daily
Cycloserine/terizidone PO
250–750 mg daily
d
to achieve serum
20–35 mg/L in plasma
e
4 Amikacin IV / IM 15 mg/kg daily
Streptomycin IV / IM 15 mg/kg daily. Some clinicians
prefer 25 mg/kg 3 × weekly.
