Table 1. Some Drugs Which May Cause Idiosyncratic Liver Injury Leading to Acute Liver Failure
Isoniazid
Sulfasalazine Phenytoin Statins
Propylthiouracil Ciprofloxacin Nitrofurantoin Disulfiram Cocaine
Valproic acid Amiodarone Dapsone Etodolac
Didanosine Efavirenz
Carbamazepine Valproic Acid
Pyrazinamide Isoflurane
Itraconazole Nicotinic acid Imipramine Gemtuzumab Terbinafine Methyldopa
MDMA (Ecstasy) Labetalol Tolcapone Allopurinol Methyldopa Ketoconazole Abacavir
Doxycycline Diclofenac
Combination agents with enhanced toxicity: Trimethoprim-sulfamethoxazole Rifampin-Isoniazid Amoxicillin-clavulanate
Some herbal products/dietary supplements that have been associated with hepatotoxicity include:
Kava Kava Herbalife
Hydroxycut Comfrey Senecio
Greater celandine He Shon Wu LipoKinetix Ma Huang
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