Treatment
Table 6. Adult Dosage of Nucleoside Analogue in Accordance with Creatinine Clearance (ClCr Drug
ClCr (mL/min)
≥ 50 30-49 15-29 10-29 10-19 5-14 < 10 < 5
Hemodialysis patients
Hemodialysisa or continuous ambulatory peritoneal dialysis
End-stage renal disease
a Administer after hemodialysis.
10 mg every week following dialysis
0.05 mg qd or 0.5 mg
q 7 days
0.1 mg qd or 1 mg
q 7 days
600 mg once every 96 hra
300 mg once a week or after a total of approximately 12 hr of dialysis
0.05 mg qd or 0.5 mg
q 7 days
0.1 mg qd or 1 mg
q 7 days
35 mg first dose, then 10 mg qd
10 mg every third day
35 mg first dose, then 15 mg qd
0.15 mg qd or 0.5 mg
q 72 hr
0.3 mg qd or 1 mg
q 72 hr
(Not requiring dialysis) 600 mg once every 72 hr
(Without dialysis) No recom- mendation
Adefovir Hepsera®
10 mg daily (I)
10 mg every other day
Entecavir Baraclude®
0.5 mg qd (I)
0.25 mg qd or 0.5 mg
q 48 hr
Entecavir (lamivudine refractory/ resistant)
0.5 mg qd or 1 mg
q 48 hr
Lamivudine Epivir®
1 mg qd (I) 100 mg qd (I)
100 mg first dose, then 50 mg qd
100 mg first dose, then 25 mg qd
300 mg q 72-96 hr
Telbivudine Tyzeka®
600 mg once every 48 hr
)
Tenofovir Viread®
600 mg once daily (I) 300 mg
300 mg q 48 hr
q 24 hr (I)
10
