Diagnostic Criteria ÎChronic hepatitis B
• HBsAg-positive > 6 months • Serum HBV DNA > 20,000 IU/mL (105 Lower values — 2,000-20,000 IU/mL (104 HBeAg-negative chronic hepatitis B
copies/mL). -105
copies/mL) — are oſten seen in
• Persistent or intermittent elevation in alanine aminotransferase/aspartate aminotransferase (ALT/AST) levels
• Liver biopsy showing chronic hepatitis with moderate or severe necroinflammation
ÎInactive HBsAg carrier state
• HBsAg-positive > 6 months • HBeAg(−), anti-HBe(+) • Serum HBV DNA < 2,000 IU/mL • Persistently normal ALT/AST levels • Liver biopsy confirms absence of significant hepatitis
ÎResolved hepatitis B
• Previous known history of acute or chronic hepatitis B or the presence of hepatitis B core antibody (anti-HBc) ± hepatitis B surface antibody (anti-HBs)
• HBsAg(−) • Undetectable serum HBV DNA* • Normal ALT levels
*Very low levels may be detectable using sensitive polymerase chain reaction (PCR) assays.
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