Table 1. Regimens for Treatment of Stage IV NSCLC ( for a patient with BSA 1.96 [weight - 81.5 kg, height - 169 cm])
Treatment Setting
1st line Drug Bevacizumab Initial Dose
15 mg/kg (recommended only in combination with carboplatin/ paclitaxel)a
1st 1st
line line
Carboplatin Cetuximab
700 mga 400 mg/m2
dose followed by 250 mg/m2 (recommended only in combination with cisplatin/ vinorelbine)a
initial
1st 1st
line
2nd 1st 1st
1st
1st 1st
& 2nd line
& 2nd line
line line & 2nd line 1st a line line line
Cisplatin Docetaxel Erlotinib Gefitinib
Gemcitabine Irinotecan Paclitaxel Pemetrexed Vinorelbine
75 mg/m2 75 mg/m2
150 mg per daya 250 mg per daya 1250 mg/m2 a
60 mg/m2 200 mg/m2
500 mg/m2 (note: monotherapy in second-line setting)a
25 mg/m2 Regimen Every three weeks
Every three weeks Weekly
Every three weeks Every three weeks Daily Daily
Days 1 & 8, then every three weeks
Days 1, 8 & 15, then every four weeks
Every three weeks Every three weeks
Days 1 & 8, then every three weeks
These doses are specifically enumerated in the guideline; the other doses are based on doses used in major clinical trials.
