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Recommendation Grading A Directly based on meta-analysis of RCTs, Well-designed RCTs or diagnostic studies performed on a population similar to the guideline's target population B Directly based on RCTs or diagnostic studies with minor limitations; overwhelmingly consistent evidence from observational studies C Directly based on observational studies (case control and cohort design) D Directly based on expert opinion, case reports, nonsystematic reviews. LB Laboratory based NR Not Rated 106 Commerce Street, Suite 105 Lake Mary, FL 32746 TEL: 407.878.7606 • FAX: 407.878.7611 Order additional copies, at Copyright © 2017 All rights reserved AAAAIURT17012b Disclaimer is Guideline attempts to define principles of practice that should produce high-quality patient care. It focuses on the needs of primary care practice, but also is applicable to providers at all levels. is Guideline should not be considered exclusive of other methods of care reasonably directed at obtaining the same results. e ultimate judgment concerning the propriety of any course of conduct must be made by the clinician aer consideration of each individual patient situation. Neither IGC, the medical associations, nor the authors endorse any product or service associated with the distributor of this clinical reference tool. Source Bernstein JA, Lang DM, Khan DA, et al. e diagnosis and management of acute and chronic urticaria: 2014 update. J Allerg y Clin Immunol. 2014;133(5):1270-7. Abbreviations ACE, angiotensin-converting enzyme; APST, autologous plasma skin test; ASST, autologous serum skin test; BUN, blood urea nitrogen; CBC, complete blood count; CIU, chronic idiopathic urticaria; Cr, creatinine; CU, chronic urticaria; CUA, chronic urticaria and angioedema; DPUA, delayed pressure urticaria/angioedema; DRESS, drug-related rash with eosinophilia and systemic symptoms; EIAn, exercise-induced anaphylaxis; ESR, erythrocyte sedimentation rate; FMF, familial Mediterranean fever; G6PD, glucose-6-phosphate dehydrogenase; HES, hypereosinophilic syndrome; HUVS, hypocomplementemic urticarial vasculitis syndrome; Ig, immune globulin; hyper-IgD, hyper-IgD syndrome with periodic fever; K, potassium; LFT, liver function test; MWS, Muckle-Wells syndrome; NA, not available; NOMID, neonatal-onset multisystem inflammatory disease, also known as chronic infantile neurologic, cutaneous and articular syndrome; NSAID, nonsteroidal anti-inflammatory drug ; PAPA, pyogenic arthritis, pyoderma gangrenosum and acne syndrome; PFAPA, periodic fevers with aphthous stomatitis, pharyngitis and adenitis; PUPPS, pruritic urticarial papules and plaques of pregnancy; RCT, randomized controlled trial; SLE, systemic lupus erythematosus; SM, systemic mastocytosis; t1/2, half-life; t max , time of maximum concentration; TMEP, telangiectasia macularis eruptiva perstans; TNF, tumor necrosis factor; TRAPS, TNF receptor-associated fever syndrome; TSH, thyroid-stimulating hormone; UP, urticaria pigmentosa

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