10
Treatment
Streptomycin Aqueous solution (1 g vials) for IM or IV
administration
Adults
Children
Amikacin/
kanamycin
Aqueous solution (500 mg and 1 g vials) for IM or IV
administration
Adults
Children
Capreomycin Aqueous solution (1 g vials) for IM or IV
administration
Adults
Children
Para-amino
salicylic acid
Granules (4 g packets) can be mixed in and ingested
with so food (granules should not be chewed). Tablets
(500 mg ) are still available in some countries, but not in
the United States. A solution for IV administration is
available in Europe.
Adults
Children
Levofloxacin Tablets (250 mg, 500 mg, 750 mg ); aqueous solution
(500 mg vials) for IV injection
Adults
Children
Moxifloxacin Tablets (400 mg ); aqueous solution (400 mg/ 250 mL)
for IV injection
Adults
Children
a
Dosing based on actual weight is acceptable in patients who are not obese. For obese patients (>20%
above ideal body weight [IBW]), dosing based on IBW may be preferred for initial doses. Some
clinicians prefer a modified IBW (IBW + [0.40 x (actual weight – IBW)]) as is done for initial
aminoglycoside doses. Because tuberculosis drug dosing for obese patients has not been established,
therapeutic drug monitoring may be considered for such patients.
b
For purposes of this document, adult dosing begins at age 15 years or at a weight of >40 kg in younger
children. e optimal doses for thrice-weekly therapy in children and adolescents have not been
established. Some experts use in adolescents the same doses recommended for adults, and for younger
children the same doses recommended for twice-weekly therapy.
c
Higher doses of rifampin, currently as high as 35 mg/kg, are being studied in clinical trials.
d
Rifabutin dose may need to be adjusted when there is concomitant use of protease inhibitors or non-
nucleoside reverse transcriptase inhibitors.
e
TBTC Study 22 used rifapentine (RPT) dosage of 10 mg/kg in the continuation phase of treatment
for active disease. However, RIFAQUIN and PREVENT TB safely used higher dosages of RPT,
administered once weekly. Daily doses of 1200 mg RPT are being studied in clinical trials for active
tuberculosis disease.
Table 2. Doses
a
of Antituberculosis Drugs for Adults and
Children
b
(cont'd)
Drug Preparation Population
