Steroidal
Estradiol 2 mg PO tid Boxed Warning :
• Risk of endometrial cancer
• Cardiovascular and other risks
Fluoxymesterone Not FDA-approved for breast cancer
Contraindications:
• Known hypersensitivity
• Women known or suspected to be
pregnant
• Patients with serious cardiac,
hepatic or renal disease
Megestrol acetate 160 mg PO qd Contraindications:
• Hypersensitivity
Warnings:
• Embryo-fetal toxicity
Macrolide immunosuppressant – rapamycin (mTOR) inhibitor
Everolimus Not FDA-approved for breast cancer
Boxed Warning :
• Malignancies and serious infections
• Kidney graft thrombosis
• Nephrotoxicity
• Mortality in heart transplantation
Table 1. Recommended Pharmaceuticals for HR+
Breast Cancer (cont'd)
Agent Dose Comments
