Table 1. Recommended Pharmaceuticals for HR+
Breast Cancer
Agent Dose Comments
Antiestrogen
Tamoxifen 20–40 mg Boxed Warning :
• Uterine malignancies
• Stroke
• Pulmonary embolism
Aromatase inhibitors
Anastrozole 1 mg PO qd Contraindications:
• Women of premenopausal
endocrine status, including
pregnant women
• Known hypersensitivity
Exemestane 25 mg PO qd aer
a meal
Contraindications:
• Known hypersensitivity
Letrozole 2.5 mg PO qd Contraindications:
• Women of premenopausal
endocrine status, including
pregnant women
CDK 4/6 kinase inhibitor
Palbociclib 125 mg PO qd taken
with food for 21 days
followed by 7 days off
treatment
Should be reserved for patients
without prior exposure to cyclin-
dependent kinase 4/6 inhibitors
Warnings:
• Neutropenia
• Pulmonary Embolism
• Embryo-fetal toxicity
Estrogen receptor antagonist
Fulvestrant 500 mg IM every
2 weeks for three cycles
Contraindications:
• Hypersensitivity
Warnings:
• Use a 250 mg dose for patients with
moderate hepatic impairment
• Risk of bleeding
• Embryo-fetal toxicity
Treatment
