Selecting a Treatment Regimen
Table 5A. Characteristics of Nucleoside Reverse Transcriptase Inhibitors (NRTIs)
Drug
Abacavir (ABC) Ziagen®
ABC/ZDV/3TC Trizivir®
ABC/3TC Epzicom®
Formulation
300 mg tablets or 20 mg/mL oral solution
ABC 300 mg + ZDV 300 mg + 3TC 150 mg
Dosing Recommendations
300 mg bid or 600 mg once daily
▶ Take without regard to meals 1 tablet bid
ABC 600 mg + 3TC 300 mg 1 tablet once daily
Didanosine (ddI)
Videx EC® Generic ddI EC
Videx EC® 125, 200, 250, 400 mg capsules ▶ Buffered tablets (non-EC) no longer available
Videx® 10 mg/mL oral solution
Body weight ≥ 60 kg: 400 mg once dailya ▶ With TDF, 250 mg once daily
Body weight < 60 kg: 250 mg once dailya ▶ With TDF, 200 mg once daily
▶ Take 1/2 hour before or 2 hours after a meal
a
Preferred dosing with oral solution is bid (total daily dose divided into 2 doses)
Emtricitabine (FTC) Emtriva®
FTC/TDF/EFV Atripla®
FTC/TDF/RPV Complera™
FTC/TDF Truvada®
8
200 mg hard gelatin capsule or 10 mg/mL oral solution
FTC 200 mg + TDF 300 mg + EFV 600 mg
FTC 200 mg + TDF 300 mg + RPV 25 mg
200 mg capsule once daily or 240 mg (24 mL) oral solution once daily
▶ Take without regard to meals 1 tablet at or before bedtime
▶ Take on an empty stomach to reduce side effects
One tablet once daily with meal FTC 200 mg + TDF 300 mg 1 tablet once daily
Also available in:
Also available in:
