Selecting a Treatment Regimen
Table 5A. Characteristics of Nucleoside Reverse Transcriptase Inhibitors (NRTIs)
Drug
Lamivudine (3TC) Epivir®
3TC/ZDV Combivir®
3TC/ABC Epzicom®
3TC/ZDV/ABC Trizivir®
Stavudine (d4T)
Zerit® Generic
Formulation
150, 300 mg tablets or 10 mg/mL oral solution
Dosing Recommendations
150 mg bid or 300 mg once daily ▶ Take without regard to meals
3TC 150 mg + ZDV 300 mg 1 tablet bid 3TC 300 mg + ABC 600 mg 1 tablet once daily 1 tablet bid
3TC 150 mg + ZDV 300 mg + ABC 300 mg
15, 20, 30, 40 mg capsules or 1 mg/mL oral solution
Body weight ≥ 60 kg: 40 mg bid Body weight < 60 kg: 30 mg bid b ▶ Take without regard to meals
b
WHO recommends 30 mg bid dosing regardless of body weight
Tenofovir Disoproxil Fumarate (TDF) Viread®
150, 200, 250, 300 mg tablets or 40 mg/1 gm oral powder
Adults: 300 mg once daily Children ≥ 2 years: ≥ 17 kg: tablets based on body weight (see PI) or oral powdera 8 mg/kg once daily Max: 300 mg/d < 17 kg: oral powdera
once daily Max: 300 mg/d
FTC/TDF/EFV Atripla®
FTC/TDF/RPV Complera™
FTC/TDF Truvada®
Zidovudine (AZT, ZDV)
Retrovir® Generic
3TC/ ZDV Combivir®
3TC/ABC/ZDV Trizivir®
10
FTC 200 mg + TDF 300 mg + EFV 600 mg
FTC 200 mg + TDF 300 mg + RPV 25 mg
100 mg capsules, 300 mg tablets, 10 mg/mL intravenous solution, 10 mg/mL oral solution
3TC 150 mg + ABC 300 mg + ZDV 300 mg
a Oral powder should be taken with food 8 mg/kg
1 tablet at or before bedtime ▶ Take on an empty stomach to reduce side effects
One tablet once daily with meal FTC 200 mg + TDF 300 mg 1 tablet once daily
300 mg bid or 200 mg tid ▶ Take without regard to meals
3TC 150 mg + ZVD 300 mg 1 tablet bid 1 tablet bid
Also available in:
Also available in:
Also available in:
