Microorganisms Causing NVO
Alternatives
a
Comments
d
• Vancomycin IV 15-20 mg/kg q12h
c
OR
• Daptomycin 6-8 mg/kg IV q24h OR
• Linezolid 600 mg PO/IV q12h OR
• Levofloxacin PO 500-750 mg PO q24h and
rifampin PO 600 mg daily OR
• Clindamycin IV 600-900 mg q8h
6 weeks duration
• Daptomycin 6-8 mg/kg IV q24h OR
• Linezolid 600 mg PO/IV q12h OR
• Levofloxacin PO 500-750 mg PO q24h and
rifampin PO 600 mg daily
6 weeks duration
• Vancomycin 15-20 mg/kg IV q12h (consider
loading dose, monitor serum levels) OR
• Daptomycin 6 mg/kg IV q24h OR
• Linezolid 600 mg PO Or IV q12h
Recommend the addition of 4-6 weeks of
aminoglycoside therapy in patients with
infective endocarditis. In patients with
bloodstream infection physicians may opt
for a shorter duration of therapy. Optional
for other patients. Vancomycin should be
used only in case of penicillin allerg y.
• Daptomycin 6 mg IV q24h OR
• Linezolid 600 mg PO or IV q12h
Recommend the addition of 4-6 weeks of
aminoglycoside therapy in patients with
infective endocarditis. In patients with
bloodstream infection physicians may opt
for a shorter duration of aminoglycoside.
e additional of aminoglycoside is
optional for other patients.
• Ciprofloxacin 750 mg PO q12h
(or 400 mg IV q8h) OR
• Aztreonam 2 g IV q8h for severe penicillin
allerg y and quinolones resistant strains OR
• Ceftazidime 2g IV q8h
• 6 weeks duration
• Double coverage may be considered
(i.e., Beta lactam and ciprofloxacin or
beta lactam and an aminoglycoside)
• Ciprofloxacin 500 -750 mg PO q12h or 400
mg IV q12h
6 weeks duration
• Vancomycin IV 15-20 mg/kg q12h consider
loading dose, monitor serum levels)
• 6 weeks duration
• Vancomycin only in case of allerg y
• Clindamycin 600-900 mg IV q8h OR
• Vancomycin IV 15-20 mg/kg q12h (consider
loading dose, monitor serum levels)
• 6 weeks duration
• Vancomycin only in case of allerg y
• Ceftriaxone 2 g IV q24h (if nalidixic acid
resistant )
6-8 weeks duration
should be chosen based on in vitro susceptibility as well as patient allergies, intolerances and potential drug