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Skin and Soft Tissue Infections

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19 Pediatric Dosage beyond the Neonatal Period a Antimicrobial Agent for Patients with Severe Penicillin Hypersensitivity 60-75 mg/kg/dose of the piperacillin component q6h IV 10-13 mg/kg/dose q8h IV Clindamycin or metronidazole b with an aminoglycoside or fluoroquinolone. N/A N/A 20 mg/kg/dose q8h IV N/A 15 mg/kg/dose q12h IV for children 3 months to 12 years N/A 50 mg/kg/dose q6h IV 7.5 mg/kg/dose q6h IV 10-13 mg/kg/dose q8h IV N/A 60,000-100,000 u/kg/dose q6h IV 10-13 mg/kg/dose q8h IV Vancomycin, linezolid, quinupristin/ dalfopristin, daptomycin 50 mg/kg/dose q6h IV Vancomycin, linezolid, quinupristin/ dalfopristin, daptomycin 50 mg/kg/dose q6h IV 33 mg/kg/dose q8h IV 15 mg/kg/dose q6h IV N/A 10-13 mg/kg/dose q8h IV Bacteriostatic; potential cross-resistance and emergence of resistance in erythromycin- resistant strains; inducible resistance in MRSA. c 10-13 mg/kg/dose q8h IV 60,000-100,00 u/kg/dose q6h IV N/A NOT recommended for children, but may need to use in life-threatening situations. N/A NOT recommended for children, but may need to use in life-threatening situations. N/A

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