Treatment
20
Table 3. Antibiotics for Treatment of Incisional Surgical Site
Infections
Surgery of Intestinal or Genitourinary Tract
Single-drug regimens Ticarcillin-clavulanate 3.1 g q6h
Piperacillin-tazobactam 3.375 g q6h or 4.5 g q8h
Imipenem-cilastatin 500 mg q6h
Meropenem 1 g q8h
Ertapenem 1 g q24h
Combination regimens Ceriaxone 1 g q24h plus metronidazole 500 mg q8h
Ciprofloxacin 400 mg IV q12h or 750 mg PO q12h plus
metronidazole 500 mg q8h
Levofloxacin 750 mg q24h plus metronidazole 500 mg q8h
Ampicillin-sulbactam 3 g q6h plus gentamicin or
tobramycin 5 mg/kg q24h
Surgery of Trunk or Extremity away from Axilla or Perineum
Oxacillin or nafcillin 2 g q6h
Cefazolin 0.5-1 g q8h
Cephalexin 500 mg PO q6h
SMX-TMP 160-800 mg PO q6h
Vancomycin 15 mg/kg q12h
Surgery of Axilla or Perineum
a
Metronidazole 500 mg q8h
plus ciprofloxacin 400 mg IV q12h or 750 mg PO q12h
OR
levofloxacin 750 mg q24h
OR
ceriaxone 1 g q24h
a
May also need to cover for MRSA with vancomycin 15 mg/kg q12h.
