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Management
8.3.2. Inpatient Initiation of Antiarrhythmic Agents
COR LOE
Recommendations
1 A 1. Patients with AF who are initiating, increasing the dose of,
or reinitiating dofetilide therapy should be admitted for a
minimum of 3 days to a facility that can provide continuous
electrocardiographic monitoring, calculations of CrCl, and
cardiac resuscitation, given the potential for proarrhythmia.
2a B-R 2. In patients with AF, it is reasonable to initiate sotalol therapy
in a facility that can provide continuous electrocardiographic
monitoring, calculations of CrCl, and cardiac resuscitation,
given the potential for proarrhythmia and bradycardia.
2a B-NR 3. In patients with AF who are initiating PITP dosing of flecainide
and propafenone with concomitant AV nodal blocking drugs,
it is reasonable to receive the first dose in a facility that can
provide continuous electrocardiographic monitoring, given the
potential for proarrhythmia.
