99
Elimination
Half-Life
Mechanism of
Action
Major Adverse
Effects
Important Pharmacokinetic
Drug Interactions
9 h Inhibits I
Na
Atrial flutter
Bradycardia
AV block
Dizziness
Dyspnea
Exacerbation of
HFrEF
Nausea
Taste disturbances
VT
Visual
disturbances
Propafenone is a substrate for
CYP 2D6
e following drugs may
increase plasma propafenone
concentrations:
Fluoxetine
Paroxetine
Propafenone may increase
plasma digoxin concentrations
Propafenone may
increase plasma warfarin
concentrations
12 h Inhibits I
Kr
Betablocker
d-Sotalol
augments late I
Na
AV block
Bradycardia
Bronchospasm
Diarrhea
Exacerbation of
HFrEF
Fatigue
Nausea and
vomiting
QT prolongation
TdP
None
