98
Management
Table 23. Specific Drug Therapy for Maintenance of Sinus
Rhythm in Patients With Atrial Fibrillation
Drug Loading Dose Maintenance Dose
Primary
Route(s) of
Elimination
Propafenone N/A 150–300 mg/ PO q 8 h, ER
225–425 PO q 12 h
Liver
Sotalol CrCl >60 mL/
min: 40–80 mg
twice daily for 3 d
CrCl: 40–60
mL/min: 80 mg
once daily for 3 d
CrCl <40
mL/min:
Contraindicated
CrCl >60 mL/min: 80–160 mg
twice daily
CrCl: 40-60 mL/min: 80–160
mg once daily
CrCl <40 mL/min:
Contraindicated
Kidney
* Moderate inhibitor: causes a 2-fold to <5-fold increase in AUC or a 50% to 80% decrease in
clearance.
†
Mild inhibitor: causes a ≥1.25-fold but <2-fold increase in AUC or a 20% to 50% decrease
in clearance.
‡
Lovastatin doses should not exceed 40 mg daily in patients taking amiodarone.
§
Simvastatin doses should not exceed 20 mg daily in patients taking amiodarone.
||
Simvastatin doses should not exceed 10 mg daily in patients taking dronedarone.
¶
% of a dose excreted unchanged in urine.
(cont'd)
