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Table 6. Dosing of Antiretroviral Agents (cont'd)
Trade Name
Contents
Usual Daily
Dose
a
Dosing in Renal
Insufficiency
b
Dosing in Hepatic
Impairment
Selecting a Treatment Regimen
Fixed-dose Combinations
Atripla
®
FTC 200 mg +
EFV 600 mg +
TDF 300 mg
1 tablet PO
once daily
NOT recommended
for use in patients with
CrCl <50 mL/min.
Instead use the individual
drugs of the fixed-dose
combination and adjust
TDF and FTC doses
according to CrCl level.
Child-Pugh Class A:
• No dosage adjustment
Child-Pugh Class B/C:
• NOT recommended
Biktarvy
®
BIC 50 mg +
FTC 200 mg +
TAF 25 mg
1 tablet PO
once daily
NOT recommended for
use in patients with CrCl
<30 mL/min
Child-Pugh Class C:
• NOT recommended
Combivir®
3TC 150 mg
ZDV 300 mg
1 tablet PO bid CrCl <50 mL/min
NOT recommended
• Monitor for hematologic
toxicity
Complera
®
FTC 200 mg +
RPV 25 mg +
TDF 300 mg
1 tablet PO
once daily
NOT recommended
for use in patients with
CrCl <50 mL/min.
Instead use the individual
drugs of the fixed-dose
combination and adjust
TDF and FTC doses
according to CrCl level.
Child-Pugh Class A/B:
• No dosage adjustment
Child-Pugh Class C:
• No dosage
recommendation
Descovy
®
FTC 200 mg +
TAF 25 mg
• TAF 10 mg
PO daily
with EVG/c
(Genvoya), or
• TAF 25 mg
PO daily
in other
fixed-dose
combinations
NOT recommended
for use in patients with
CrCl <30 mL/min or
on HD
c
Child-Pugh Class A/B:
• No dosage adjustment
Child-Pugh Class C:
• No dosage
recommendation
Epzicom
®
ABC 600 mg +
3TC 300 mg
1 tablet PO
once daily
NOT recommended
for use in patients with
CrCl <50 mL/min
Child-Pugh Class A:
• 200 mg PO bid
(use oral solution)
Child-Pugh Class B/C:
• Contraindicated
