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Table 6. Dosing of Antiretroviral Agents (cont'd)
Trade Name
Contents
Usual Daily
Dose
a
Dosing in Renal
Insufficiency
b
Dosing in Hepatic
Impairment
Genvoya
®
FTC 200 mg +
EVG 150 mg +
COBI 150 mg +
TAF 10 mg
1 tablet PO
once daily with
food
NOT recommended
for use in patients with
CrCl <30 mL/min
Mild-to-Moderate
Hepatic Insufficiency:
• No dosage adjustment
necessary
Severe Hepatic
Insufficiency:
• NOT recommended
Odefsey
®
FTC 200 mg +
RPV 25 mg +
TAF 25 mg
1 tablet PO
once daily with
food
NOT recommended
for use in patients with
CrCl <30 mL/min
Child-Pugh Class A/B:
• No dosage adjustment
Child-Pugh Class C:
• No dosage
recommendation
Stribild
®
FTC 200 mg +
EVG 150 mg +
COBI 150 mg +
TDF 300 mg
1 tablet once
dailyPO
EVG/c/TDF/FTC
should NOT be
initiated in patients
with CrCl <70 mL/min.
Discontinue EVG/c/
TDF/FTC if CrCl
declines to <50 mL/min
while patient is on
therapy.
Mild-to-Moderate
Hepatic Insufficiency:
• No dosage adjustment
necessary
Severe Hepatic
Insufficiency:
• NOT recommended
Triumeq
®
DTG 50 mg +
ABC 600 mg +
3TC 300 mg
1 tablet PO
daily without
regard to meals
NOT recommended
for use in patients with
CrCl <50 mL/min
Child-Pugh Class A:
• 200 mg PO bid
(use oral solution)
Child-Pugh Class B/C:
• Contraindicated
Trizivir
®
3TC 150 mg
ABC 300 mg
ZDV 300 mg
1 tablet PO bid CrCl <50 mL/min
NOT recommended
Child-Pugh Class A:
• May required
adjustment of abacavir
dose
Child-Pugh Class B/C:
• Contraindicated
Truvada
®
FTC 200 mg +
TDF 300 mg
1 tablet PO
once daily
CrCl
(mL/min)
Dose No dosage
recommendation
30–49 1 tablet q48h
<30 or
on HD
NOT rec.
rec., recommended or recommendation
a
Refer to full guideline for additional dosing information.
b
Including with chronic ambulatory peritoneal dialysis and hemodialysis.
c
On dialysis days, take dose aer HD session.
