20
Selecting a Treatment Regimen
Nelfinavir
(NFV)
Viracept
®
1250 mg PO bid No dosage
adjustment
necessary
Mild Hepatic
Impairment:
• No dosage adjustment
Moderate-to-Severe
Hepatic Impairment:
• Do NOT use
Ritonavir
(RTV)
Norvir
®
As a PI-Boosting
Agent:
• 100–400 mg
per day
No dosage
adjustment
necessary
Refer to
recommendations for the
primary PI.
Saquinavir
(SQV)
Invirase
®
SQV 1000 mg +
RTV 100 mg PO
bid
No dosage
adjustment
necessary
Mild-to-Moderate
Hepatic Impairment:
• Use with caution
Severe Hepatic
Impairment:
• Contraindicated
Tipranavir
(TPV)
Aptivus
®
TPV 500 mg +
RTV 200 mg PO
bid
No dosage
adjustment
necessary
Child-Pugh Class A:
• Use with caution
Child-Pugh Class B/C:
• Contraindicated
Darunavir/
COBI
(DRV/c)
Prezcobix
®
1 tablet PO
once daily
(recommended
only for patients
without DRV-
associated resistance
mutations)
If Used with TDF:
NOT recommended
for use in patients
with CrCl <70 mL/
min
Child-Pugh Class A/B:
• No dosage adjustment
Child-Pugh Class C:
• NOT recommended
Table 6. Dosing of Antiretroviral Agents (cont'd)
ARVs
Generic Name
(Abbreviation)
Trade Name
Usual Daily
Dose
a
Dosing in Renal
Insufficiency
b
Dosing in Hepatic
Impairment
