19
Table 6. Dosing of Antiretroviral Agents (cont'd)
ARVs
Generic Name
(Abbreviation)
Trade Name
Usual Daily
Dose
a
Dosing in Renal
Insufficiency
b
Dosing in Hepatic
Impairment
Darunavir
(DRV)
Prezista
®
ARV-Naive
Patients and
ARV-Experienced
Patients with No
DRV Resistance
Mutations:
• DRV 800 mg +
RTV 100 mg PO
once daily
ARV-Experienced
Patients with ≥1
DRV Resistance
Mutation:
• DRV 600 mg
+ RTV 100 mg
PO bid
No dosage
adjustment
necessary
Mild-to-Moderate
Hepatic Impairment:
• No dosage adjustment
Severe Hepatic
Impairment:
• NOT recommended
Fosamprenavir
(FPV)
Lexiva
®
• 1400 mg PO
bid, or
• FPV 1400 mg +
RTV 100–200
mg PO once
daily, or
• FPV 700 mg +
RTV 100 mg
PO bid
No dosage
adjustment
necessary
PI-Naive Patients Only
Child-Pugh Score 5–9:
• 700 mg bid
Child-Pugh Score 10–15:
• 350 mg bid
PI-Naive or PI-
Experienced Patients
Child-Pugh Score 5–6:
• 700 mg bid + RTV 100
mg once daily
Child-Pugh Score
7–9:450 mg bid + RTV
100 mg ) once daily
Child-Pugh Score 10–15:
• 300 mg bid + RTV 100
mg once daily
Indinavir
(IDV)
Crixivan
®
800 mg PO q8h No dosage
adjustment
necessary
Mild-to-Moderate
Hepatic Insufficiency
Because of Cirrhosis:
• 600 mg q8h
Lopinavir/
Ritonavir
(LPV/r)
Kaletra
®
• LPV 400 mg +
RTV 100 mg PO
bid, or
• LPV 800 mg +
RTV 200 mg PO
once daily
Avoid once-daily
dosing in patients
on HD
No dosage
recommendation;
use with caution in
patients with hepatic
impairment.
