16
Selecting a Treatment Regimen
Table 6. Dosing of Antiretroviral Agents
ARVs
Generic Name
(Abbreviation)
Trade Name
Usual
Daily
Dose
a
Dosing in Renal
Insufficiency
b
Dosing in Hepatic
Impairment
Nucleoside Reverse Transcriptase Inhibitors (NRTIs)
Abacavir
(ABC)
Ziagen
®
300 mg PO
bid
No dosage adjustment
necessary
Child-Pugh Class A:
• 200 mg PO bid
(use oral solution)
Child-Pugh Class B/C:
• Contraindicated
Didanosine
EC
(ddI)
Videx
®
EC
Body weight
≥60 kg :
• 400 mg
PO once
daily
Body weight
<60 kg :
• 250 mg
PO once
daily
Dose (Once Daily) No dosage adjustment
necessary
CrCl
(mL/min)
≥60 kg <60 kg
30–59 200 mg 125 mg
10–29 125 mg 125 mg
<10, HD,
c
CAPD
125 mg 75 mg
oral
solution
Didanosine
Oral Solution
(ddI)
Videx
®
Body weight
≥60 kg :
• 200 mg
PO bid,
OR
• 400 mg
PO once
daily
Body weight
<60 kg :
• 250 mg
PO once
daily, OR
• 125 mg
PO bid
Dose (Once Daily) No dosage adjustment
necessary
CrCl
(mL/min)
≥60 kg <60 kg
30–59 200 mg 150 mg
10–29 150 mg 100 mg
<10, HD,
c
CAPD
100 mg 75 mg
Emtricitabine
(FTC)
Emtriva
®
200 mg oral
capsule once
daily
OR
240 mg
(24 mL)
oral solution
once daily
CrCl
(mL/min)
Capsule
Dose
Solution
Dose
No dosage
recommendation
30–49 200 mg
q48h
120 mg
q24h
15–29 200 mg
q72h
80 mg
q24h
<15 or
on HD
c
200 mg
q96h
60 mg
q24h
