Antiretroviral Agents in HIV-1 (2018)

Antiretroviral Agents in HIV-1 Pocket Guide

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17 Lamivudine (3TC) Epivir ® 300 mg PO once daily OR 150 mg PO bid CrCl (mL/min) Dose No dosage adjustment necessary 30–49 150 mg q24h 15–29 1 × 150 mg, then 100 mg q24h 5–14 1 × 150 mg, then 50 mg q24h <5 or on HD c 1 × 50 mg, then 25 mg q24h Stavudine (d4T) Zerit ® Body weight ≥60 kg : • 40 mg PO bid, Body weight <60 kg : • 30 mg PO bid Dose No dosage recommendation CrCl (mL/min) ≥60 kg <60 kg 26–50 20 mg q12h 15 mg q12h 10–25 or on HD c 20 mg q24h 15 mg q24h Tenofovir Disoproxil Fumarate (TDF) Viread ® 300 mg PO once daily CrCl (mL/min) Dose No dosage adjustment necessary 30–49 300 mg q48h 10–29 300 mg twice weekly (every 72-96 hours) <10 and not on HD No rec. On HD c 300 mg q7d Zidovudine (ZDV) Retrovir ® 300 mg PO bid CrCl (mL/min) Dose No dosage recommendation <15 or on HD c 100 mg tid or 300 mg once daily Table 6. Dosing of Antiretroviral Agents (cont'd) ARVs Generic Name (Abbreviation) Trade Name Usual Daily Dose a Dosing in Renal Insufficiency b Dosing in Hepatic Impairment

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