17
Lamivudine
(3TC)
Epivir
®
300 mg PO
once daily
OR
150 mg PO
bid
CrCl
(mL/min) Dose
No dosage adjustment
necessary
30–49 150 mg q24h
15–29 1 × 150 mg,
then 100 mg
q24h
5–14 1 × 150 mg,
then 50 mg
q24h
<5 or on
HD
c
1 × 50 mg,
then 25 mg
q24h
Stavudine
(d4T)
Zerit
®
Body weight
≥60 kg :
• 40 mg
PO bid,
Body weight
<60 kg :
• 30 mg PO
bid
Dose No dosage
recommendation
CrCl
(mL/min)
≥60 kg <60 kg
26–50
20 mg
q12h
15 mg
q12h
10–25
or on
HD
c
20 mg
q24h
15 mg
q24h
Tenofovir
Disoproxil
Fumarate
(TDF)
Viread
®
300 mg PO
once daily
CrCl
(mL/min) Dose
No dosage adjustment
necessary
30–49 300 mg q48h
10–29 300 mg twice
weekly (every
72-96 hours)
<10 and not
on HD
No rec.
On HD
c
300 mg q7d
Zidovudine
(ZDV)
Retrovir
®
300 mg PO
bid
CrCl
(mL/min) Dose
No dosage
recommendation
<15 or on
HD
c
100 mg tid or
300 mg once
daily
Table 6. Dosing of Antiretroviral Agents (cont'd)
ARVs
Generic Name
(Abbreviation)
Trade Name
Usual
Daily
Dose
a
Dosing in Renal
Insufficiency
b
Dosing in Hepatic
Impairment