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Testosterone Therapy in Men with Hypogonadism

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Treatment 12 Table 6. Testosterone Formulations Available Outside the United States, but Not Approved by the FDA Formulation Typical Starting Doses Pharmacokinetic Profile Oral T undecanoate 40–80 mg oral, two or three times daily with meals When administered in castor oil, T undecanoate is absorbed through the lymphatics, bypassing the portal system; considerable variability in the same individual on different days and among individuals T-in-adhesive matrix patch Two 60 cm 2 patches delivering ~4.8 mg Restores serum T, DHT, and E2 to the physiological range

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