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Management
Section 8. Immunoglobulin Replacement
Recommendation 8.1
➤ We recommend immunoglobulin replacement therapy (IgRT) for
patients with IEI with IgG antibody deficiency. (S-H)
Recommendation 8.2
➤ We recommend that initial dosing of immunoglobulin for replacement
therapy be at 400 mg/kg to 600 mg/kg per month, followed by dose
adjustment, if necessary. (S-M)
Recommendation 8.3
➤ We recommend the monitoring of serum IgG levels, complete blood
cell counts with differential, and serum chemistry panel for patients
on immunoglobulin replacement therapy. (S-M)
Recommendation 8.4
➤ We recommend maintaining serum IgG levels at more than 800 mg/dL
to improve outcomes. (S-H)
Recommendation 8.5
➤ We recommend that immunoglobulin replacement therapy is
indicated as a continuous therapy for IEI. (S-L)
Recommendation 8.6
➤ We recommend that a low or absent IgA level, in the setting of low
IgG levels, is not a contraindication for immunoglobulin replacement
therapy. (S-M)
Recommendation 8.7
➤ We suggest that the route of immunoglobulin replacement therapy be
determined based on patient tolerance or preference. (C-M)
