14
Description of Conditions Description of Conditions
Effects of Adiposopathy on CKM and Other Systems
(cont'd)
System Key Concepts
Renal/urologic
• Focal segmental
glomerulosclerosis
(FSGS)
• Stress incontinence
• Hemodynamic stress increases renal
plasma flow and hyper-filtration leading
to glomerulomegaly.
• Low-grade chronic inflammation leads to
podocyte injury and FSGS.
• Increased intraabdominal pressure
combined with disrupted collagen
metabolism contributes to stress
incontinence.
Gynecologic/
reproductive
• Premature or delayed
puberty
• Menstrual cycle
irregularities
• Polycystic ovary
syndrome (PCOS)
• Infertility
• Male hypogonadism
• Uterine fibroids
• Chronic low-grade inflammation,
endocrine dysregulation, and disrupted
neurohormonal signaling lead to HPO
axis dysfunction.
• Women with PCOS often have insulin
resistance.
• Elevated leptin levels contribute to the
growth of uterine fibroids.
• Pain signaling is disrupted in menstrual
irregularities and uterine fibroids.
Dermatologic
• Acanthosis nigricans
• Hidradenitis
suppurativa (HS)
• Cellulitis
• Venous stasis
• Increased insulin stimulates insulin-
like growth factor-1 (IGF-1) receptors on
keratinocytes in acanthosis nigrans.
• Chronic low-grade inflammation
and increased mechanical f riction
exacerbates HS and cellulitis.
• Impaired healing f rom tissue hypoxia is
seen in cellulitis.
• Increased intraabdominal pressure
increases venous pressure, leading to
stasis.
